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Prior-Authorization Oncology Review Agent using LangChain and Llama 3.3 70B

Processing oncology prior-authorization requests demands aligning patient gene mutant dosage against metastatic tropism evidence. Build a stateful LangChain and LangGraph pipeline powered by Llama 3.3 70B to evaluate unstructured clinical records and yield structured approval determinations with 90% precision.

Data ScienceHosted by Vera

What you are building

Build an enterprise oncology prior-authorization agent using LangChain, LangGraph, and Llama 3.3 70B.

How work is evaluated

Evaluation

Evaluates precision and evidence extraction accuracy of prior-authorization determinations.

Datasets

Public datasets, plus the private datasets you have access to.

How submissions are scored

Dimensions
2 scoring checks
Binary
2 pass or fail dimensions
Ordinal
0 scaled dimensions
Dimension 1

decision_validity

Checks if decision is strictly APPROVED or DENIED.

Binary check

This dimension contributes its full weight only when the submission satisfies the requirement. Partial credit is not awarded.

Dimension 2

decision_precision

Precision of approval determinations against expert oncologist consensus. • target: 0.9 • range: 0-1

Binary check

This dimension contributes its full weight only when the submission satisfies the requirement. Partial credit is not awarded.

Learning goals

  • Design stateful multi-step graphs using LangChain and LangGraph.

  • Integrate Llama 3.3 70B for clinical record processing and reasoning.

  • Parse unstructured medical records and cross-reference gene mutant dosage data.

  • Output standardized JSON prior-authorization decisions with evidence citations.

Resources

Dataset notes

De-identified synthetic prior-authorization requests combining clinical oncology progress notes with genomic sequencing reports.

Challenge setup

Evaluates precision and evidence extraction accuracy of prior-authorization determinations.

Challenge input

JSON containing patient clinical text, targeted drug, and genomic mutation profile.

LangChain

Industry standard framework for building retrieval and tool-augmented chains.

Llama 3.3 70B

High-capacity open weights model for complex clinical text reasoning.

Evaluated output

JSON with decision (APPROVED/DENIED), rationale, and cited_evidence.

Evaluation checks
  • Checks if decision is strictly APPROVED or DENIED.
  • Precision of approval determinations against expert oncologist consensus. • target: 0.9 • range: 0-1
Configured evaluation evidence
  • Benchmark: Clinical Prior-Authorization Benchmark
  • Decision Precision target: 0.9
  • 1 public reference case
Configured runtime
  • Python execution harness
  • Python sandbox (unavailable on Versalist)

Shows the first task, up to three tools, and up to three evidence items.

View technical recipe

Configured tools

Action Space
  • Llama 3.3 70B · Required
  • Langchain · Optional
  • Stainless · Optional
Orchestration
  • Langchain · Optional

Evaluation contract

  • decision_validity · Weight 1
  • decision_precision · Weight 1

Metrics

  • decision_precision · Target 0.9

Benchmarks

  • Clinical Prior-Authorization Benchmark
  • biotech

Reference cases

  • 1 public reference case

Workflow tasks

  1. Task 1

    Input: JSON containing patient clinical text, targeted drug, and genomic mutation profile.

    Output: JSON with decision (APPROVED/DENIED), rationale, and cited_evidence.

    Execution harness: Python

Evaluation tools

  • LangChain · Agent Framework
  • Llama 3.3 70B · LLM Engine

Recipe freeze marker

No recipe freeze time is recorded.

Frequently Asked Questions about Prior-Authorization Oncology Review Agent using LangChain and Llama 3.3 70B